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Protective effect of infliximab on methotrexate-induced liver injury in rats: unexpected drug interaction

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IL-6 binds to TGF- to activate the STAT3 signaling pathway [20], inducing the expression of Th17 cell-specific principal transcription factor retinoic acid receptor-related orphan receptor gamma-t (RORt), thus differentiating into Th17 cells rather than Treg cells