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The advent of long-acting analogs was therefore transformative

Chemotactic gradientsoften established by cytokines, chemokines, and damage-associated molecular patternsguide MSCs to the injury site, where they differentiate into chondrocytes

Future priorities should focus on multi-center trials for safety/PK-PD profiling, biodegradable/low-cost lipid matrix development, and omics-guided biomarker discovery to bridge translational gaps, ensuring that LBDDSs achieve their precision medicine potential in gout and hyperuricemia

Infusion times are significantly longer than other IV protocols, typically requiring two to four hours due to the need for slow administration to minimize side effects such as chest tightness, nausea, and abdominal cramping

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