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7 biggest news story of 2025: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), in widespread use to treat diabetes and obesity, have also demonstrated off-label benefits for a multitude of conditions, including cardiovascular disease, hypertension, Parkinsons, Alzheimers and some addictive disorders

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These agents may have the potential to provide disease-modifying treatment for different neurodegenerative disorders

The mechanism has been suggested to involve inhibition of cardiac intracellular signaling pathways (Ca 2+ /calmodulin-dependent protein kinase II and protein kinase C) due to saxagliptin-mediated inhibition DPP-9 (136)

We evaluated glucose excursion after intraperitoneal injection of pyruvate to further evaluate the cell-specific roles of DPP4 in regulating HGP

The ongoing clinical trial, the Restoring Insulin Secretion (RISE) Consortium, is testing whether placebo, metformin alone, liraglutide plus metformin, or insulin (3 months) followed by metformin (9 months) can preserve or improve beta cell function in individuals with early type 2 diabetes or prediabetes 48