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Examples of common comorbid conditions include asthma, allergies and autoimmune diseases

Physical activity plays a critical role, especially in preserving muscle mass

Sex-related discordance between aortic valve calcification and hemodynamic severity of aortic stenosis

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Real-world populations include a broader mix of patients, some healthier and some sicker than typical trial participants

Note: These studies provide indications of synergistic effects but are not considered definitive proof