Rat Fractalkine, FK ELISA Kit, 96T Mini dry bath Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding multiple isoforms have been observed for MED27

The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain

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Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins

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Rat Fractalkine, FK ELISA Kit, 96T Mini dry bath Alternatively spliced transcript variants encodingActs as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV: ITGB3 and ITGA4: ITGB1. Can activate integrins in both a CX3CR1 dependent and CX3CR1 independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin