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In a scientific review posted ahead of the meeting, FDA scientists reiterated their longstanding concerns

Zannad F, Ferreira JP, Pocock SJ, Anker SD, Butler J, Filippatos G, et al

7.5 Safety, sex-specificity, and CNS considerations Neuroendocrine and immunemetabolic peptides raise distinct safety considerations that must be addressed explicitly

Molecular structures and docking results were visualized with PyMOL (version 1.2), a Python-based molecular graphics system [ Docking simulations were carried out using AutoDock 4.2, developed at The Scripps Research Institute (www.scripps.edu)

65 While the traditional ketogenic diet (KD) has long been used for obesity management, it has also been associated with adverse effects on bone health, including compromised bone mass and structural integrity